Top 10 according to Destructoid.

10) Super Street Fighter II Turbo HD Remix (Q3 2008)
9) Fallout 3 (Q3 2008)
8) Alone in the Dark (Q3 2008)
7) Resistance 2 (November 2008)
6) Mirror’s Edge (TBA 2008)
5) Madden NFL 09 (August 12, 2008)
4) Metal Gear Solid 4: Guns of the Patriots (June 12, 2008)
3) The Legend of Spyro: Dawn of the Dragon (October 2008)
2) Star Wars: The Force Unleashed (September 16, 2008)
1) LittleBigPlanet (September 2008)

I'm really surprised Tom Clancy's EndWar wasn't on that list. I thought that that game looked really innovative with the voice command system. From what I've seen from other sites like ign it looks like a lot of people are anticipating the release and the ability to customize your own army and command it in a massive worldwide RTS.